A RAPID ACTING FREEZE DIRED ORAL PHARMACEUTICAL COMPOSITION FOR TREATING MIGRAINE
12) Patent Application: (11) CA 2392810
ABSTRACT:
The present invention relates to a novel freeze - dried pharmaceutical composition useful for the treatment of migraine and associated symptoms at a reduced total dose of active substance than required for oral administration in the form of a tablet comtaining a porous matrix net work of a water soluble or water dispersible carrier material, a pharmaceutically active substance(s); organoleptic additives such as sweetening agents, flavouring agents, coloring agents; pharmaceutically acceptable preservatives; solublising agents; surfaceactive agents and/or buffereing agents. The pharmaceutical composition optionally may contain other additives such as permeation enhancers, chelating salts and stabilising agents. The present invention also relates to a process for preparation of the above said composition and its use.
(72) Inventors (Country): VENKATESWARA RAO, PAVULURI (India)
KHADGAPATHI, PODILI (India)
(73) Owners (Country): NATCO PHARMA LIMITED (India)
(71) Applicants (Country): NATCO PHARMA LIMITED (India)
(74) Agent: BERESKIN & PARR
(45) Issued:
(86) PCT Filing Date: Aug. 25, 2000
(87) PCT Publication Date: June 7 , 2001
(51) International Class (IPC): A61P 25/06
A61K 31/138
A61K 9/19
A61K 31/4045
A61K 31/4196
A61K 31/42
A61K 31/48
Patent Cooperation Treaty (PCT): Yes (85) National Entry: May 29, 2002
(86) PCT Filing number: PCT/IN2000/000078
(87) International publication number: WO2001/039836
(30) Application priority data: Application No. Country Date
1160/MAS/99 India Dec. 1 , 1999
Availability of licence: N/A
Language of filing: English
Comments: 0
Votes:32